As GLP-1 agonists continue to revolutionize weight management and metabolic health, this category is also generating new opportunities in the supplement space. Since the effectiveness of GLP-1 agonists can be tempered by common side effects and metabolic challenges, this creates a timely opening for finished product formulators to develop targeted products that complement these therapies and improve the users’ experience.

Digestive Support

According to the National Library of Medicine, digestive discomfort, particularly nausea, vomiting, diarrhea and constipation, are among the most frequently reported side effects, especially in the early stages of treatment.1 Supplement solutions like probiotics offer support for gut microbiome balance, while digestive enzymes help improve meal breakdown for better nutrient absorption. Botanicals such as ginger extract and peppermint oil are also in demand for their ability to soothe the gastrointestinal tract and encourage motility, making them valuable additions to GLP-1-supportive formulas.

Metabolic Effects

Beyond digestion, consumers are looking to optimize the metabolic effects of GLP-1 therapy. Ingredients like berberine and alpha-lipoic acid (ALA) are known for supporting insulin sensitivity and glucose metabolism, while minerals such as chromium and magnesium help regulate blood sugar and cardiovascular health. These ingredients present a compelling case for formulators looking to develop products that amplify the therapeutic reach of GLP-1 medications and address adjacent health concerns.

Satiety and Body Composition

Satiety and body composition support remain critical focal points as well. Although GLP-1 agonists are potent appetite suppressants, many users turn to soluble fibers like psyllium husk and glucomannan to extend feelings of fullness and moderate digestion throughout the day. At the same time, protein ingredients are vital for preserving lean body mass during caloric restriction—a major concern during rapid weight loss phases. These additions help users maintain metabolic rate and strength while aligning with their broader fitness and wellness goals.

Liver Health

Another key consideration is liver health. GLP-1 agonists are metabolized by the liver, which can place additional stress on detoxification pathways. Ingredients such as milk thistle (standardized for silymarin) support liver cell repair and toxin clearance, while N-acetylcysteine (NAC), a precursor to glutathione, assists in detoxification and provides antioxidant protection. These nutrients are increasingly being included in supplements designed for long-term organ support during weight loss regimens.

Nutrient Depletion

Nutrient depletion is also a concern among GLP-1 users, especially due to reduced food intake. To counter this, many consumers look for B-complex vitamins, which aid in energy production, nervous system health, and mood regulation. Vitamin D, particularly when paired with K2, is popular for its multifaceted benefits across immune, skeletal, and cardiovascular systems. Including these micronutrients in formulations can help users maintain energy, resilience, and overall wellness during their lifestyle shifts.

Skin Health

Another concern gaining attention from GLP-1 users—especially those experiencing rapid weight loss—is the so-called “Ozempic face.” This term refers to the unintended side effect of facial volume loss, dry skin, and sagging, which can happen when fat is lost quickly and skin elasticity is compromised. While this is a cosmetic issue, it can impact self-esteem and has led more users to seek out nutritional solutions for skin support. Ingredients like OVOLUX™, which provides a rich blend of collagen, elastin, hyaluronic acid, glycosaminoglycans, keratin, sulfur-bearing amino acids, and calcium, can help support skin structure and hydration from within. These components play critical roles in maintaining skin elasticity, firmness, and moisture retention, helping to counteract the visible effects of weight loss and restore a more youthful, resilient appearance. For those committed to GLP-1 therapy but looking to preserve skin vitality, incorporating beauty-from-within support like OVOLUX can be a proactive, science-backed strategy.

Conclusion

Overall, individuals on GLP-1 therapies are seeking more than just weight loss—they want a comprehensive, sustainable path to health. For product formulators, this presents a strategic opportunity to create products that not only address side effects and nutrient gaps but also enhance therapeutic efficacy and long-term health outcomes. As always, care should be taken to avoid interactions, such as between fiber supplements and medication absorption, and to use clinically validated, bioavailable ingredients.

Stratum Nutrition offers a portfolio of high-quality, science-backed ingredients—such as Bimuno® GOS, Humiome® Post LB, OVOLUX™ and more—that are ideal for inclusion in products designed to support the unique needs of GLP-1 users. Whether your formulation goals involve supporting metabolic performance, helping ease digestive discomfort, or supporting detoxification, our team is here to help you develop effective, market-ready solutions that align with today’s most urgent consumer health priorities.